CASP3 and colonic neoplasm: These findings affirmed the results reported previously which have shown that FCSPs (“fucoidan”) from F. vesiculosus induce apoptosis in human lymphoma HS-Sultan cell lines and in HT-29 and HCT116 human colon cancer cells in vitro, and moreover that the exposure of these cells to the F. vesiculosus FCSPs appear to activate caspase-3 [17,18].