CASP3 and melanoma: The tumor inhibitory bioactivity of fucose-containing sulfated polysaccharides (FCSPs) from Sargassumhenslowianum C. Agardh (FSAR) and F. vesiculosus (FVES) was demonstrated through evaluation of inhibition of melanoma cell proliferation, activation of caspase-3, and apoptosis of melanoma B-16 cells in vitro.