CASP3 and malignant colon neoplasm: It has also been reported that pretreatment of HT-29 and HCT116 colon cancer cells with individual caspase-8 or caspase-9 inhibitors (Z-IETD-FMK and Z-LEHD-FMK, respectively) prior to fucoidan exposure reduced the levels of caspases, including caspase-3 [17].