UBB and nonpapillary renal cell carcinoma: Silencing of JAG2 reduced the cell number by 50–90% in a panel of eight ccRCC cell lines but not in the immortalized embryonic kidney cell line HEK293 (Supporting information, Supplementary Figure 1A); these were efficiently killed by the silencing of PLK1 and UBB (Supporting information, Supplementary Figure 1B), validating our integrative functional genomics approach for therapeutic target identification.