In a murine neuroblastoma cell line (N2a) and hippocampal slice cultures exposed to Aβ42, in APPswe/PS1, a double-transgenic mouse model for AD, and in lymphocytes of AD patients, the phosphorylation of mTOR as well as the phosphorylation of its substrate p70S6-kinase is reduced [144, 145]. This evidence concerns the gene MTOR and Alzheimer disease.