TP53 and cancer: Our meta-analysis disclosed significant correlation between REGγ and many genes in cancer and cancer related pathways from ingenuity analysis, including colorectal cancer, lung carcinoma, sarcoma, lymphoma, tumorigenesis, cell division and apoptosis related pathways etc. Importantly, genes downstream of the previously identified REGγ regulated proteins [24,25], p53, was found highly correlated with REGγ expression.