BUB3 and cancer: Based on these annotation analyses, we discovered that REGγ is linked to large numbers of cancer related genes, including Myc & RAN in oncogenic pathway, BUB3 in spindle check-point function, BTG2 in cell cycle transition, DDB1 in DNA damage repair, DAPK2 in programmed cell death, in addition to genes in the p53 pathway like PTEN.