Large extracellular pathogens face immune mechanisms that are of a TH2-type, characterized by an elevation of peripheral blood eosinophilia and accompanied by profound increases in cytokine production Interleukin (IL)-3, IL-4, IL-5, IL-9, IL-13) and granulocyte macrophage colony-stimulating factor (GM-CSF) as well as induction of the antibody isotypes immunoglobulin (Ig) G1, IgG4 and IgE. Here, IGHE is linked to Increased total eosinophil count.