Indeed, after the onset of patent infection and egg deposition in hepatic and intestinal tissues (see below) the initial prevailing TH1 response is modulated in favour of a strongly polarized TH2 response (IL-4, IL-5, IL-13) that coincides with peak granuloma formation when the eggs are produced [94] (reviewed by [95, 96]). The gene discussed is IL5; the disease is infection.