Whereas in the IL-5 knock out system hepatic granulomas are significantly smaller and IL-13-dependent tissue fibrosis reduced (although the authors examined a later time point, at +16 weeks) [123], eosinophil-lineage-negative mice (ΔdblGATA, TgPHIL) show no impaired survival after the onset of egg production up to 11 weeks post-infection. The gene discussed is IL13; the disease is infection.