In mice, adiponectin deficiency leads to exacerbated liver injuries induced by chemicals, endotoxins, alcohol consumption and obesity [21], [22], [23], [24], whereas administration of this protein protects against fatty liver diseases, as well as various other forms of hepatic injuries [17], [25], [26], [27], [28]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.