Nevertheless, a growing body of evidence suggests that UCP2 plays a beneficial role in various stages of fatty liver diseases and could exert anti-steatotic and anti-inflammatory activities through promoting mitochondrial respiration, attenuating non-esterified mitochondrial fatty acid accumulation and ROS production, inhibiting inflammatory cytokine expression and activating AMP-activated protein kinase [30], [31], [33], [35]. Here, UCP2 is linked to fatty liver disease.