Furthermore, focus is shifting towards refining the qualities in a candidate anti-tumor T cell, such as increased homeostatic proliferation and increased expression of co-stimulatory molecule CD27 along with reduced expression of regulatory molecules such as KLRG-1, CD57 and Eomes such that tumor evasive properties are effectively counteracted while optimizing the functionality of anti-tumor T cells [37]. This evidence concerns the gene KLRG1 and neoplasm.