Similarly, these same CD4+Foxp3+CD25low Tregs derived from vaccinated Foxp3GFP neu-N mice suppressed high avidity T cell IFNγ secretion in vivo after they were transferred into tumor bearing FVB/N mice treated with the 3T3neuGM vaccine and high avidity T cells (Figure 10b). The gene discussed is CD4; the disease is neoplasm.