In our model, high avidity T cells transferred into Cy-treated neu-N mice upregulated these trafficking receptors after adoptive transfer, allowing for tumor-infiltration, and tumor clearance by one week after Cy administration, which is the same time-point when depleted Treg populations begin to repopulate the tolerant host [11], and the transferred high avidity T cells lose IFNγ production. The gene discussed is IFNG; the disease is neoplasm.