Additionally, the expression of several genes involved in molecular pathways that are known to link stress with addiction and substance abuse were found to be regulated by cis-eQTLs in this study (Table S3), including several genes associated with the cAMP response element-binding (CREB) protein, a transcription factor involved in responses to stress, drug exposure, and their interacting effects [60]. Here, CREB1 is linked to substance abuse.