ATG5 and listeriosis: In addition, several top hits were tested with another intracellular pathogen, Listeria monocytogenes, and our results revealed that these IFN-γ induced beneficial genes (TNFRSF9, SERPINI1, SERPINA7, HLA-DRB1, ATG5, and ATG16L1) were also functional relevant to Listeria infection (Fig. 8), consistent with shared host response mechanisms to both intracellular pathogens, F. tularensis and L. monocytogenes.