In fact, both obesity and high fat diets are associated with increased protein expression of transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) [39], the main transcription factor regulating mitochondrial biogenesis and oxidative phosphorylation enzymes expression [40]. This evidence concerns the gene PPARGC1A and obesity due to melanocortin 4 receptor deficiency.