INSR and steatosis: Concerning hepatic histology, patients with at least moderate steatosis presented a 2.4-fold increase in phosphorylated insulin receptor (p = 0.005), a trend to a 1.4-fold increase in phosphorylated IRS-1 (p = 0.052), a 2.7-fold increase in total Akt (p = 0.015), and a 2.4-fold decrease in phosphorylated Akt levels (p = 0.004).