SLC5A5 and thyroid cancer: This technically easy strategy of using clinically proven drugs to induce NIS expression and radioiodine uptake in non-thyroid cancer cells, if confirmed to be effective in future studies, might prove to be superior to NIS expression achieved by gene transfer approaches as it can avoid certain safety, specificity, efficacy, and technical complexity issues associated with the widely investigated plasmid- or virus-mediated organ-targeted NIS gene transfer [4], [14].