CCL3 and hyperlipidemia: It is possible that chemokines within the bone marrow may mediate some of the effects of hyperlipidemia on hematopoiesis In fact, a role for CCL3 in bone marrow myeloid progenitor cell colony formation has been shown in vitro, whereby, CCL3 enhances the myelopoietic activity of mature progenitors but suppresses the myelopoietic activity of immature progenitors [33].