In this study, we have shown an interesting dichotomy that deficiency of CCL3 in bone marrow-derived cells is protective against hyperlipidemia, atherosclerosis, diet-induced obesity and hepatic steatosis; however, global deficiency of CCL3 in LDLR−/− mice seems to have little impact on these metabolic processes. This evidence concerns the gene CCL3 and obesity due to melanocortin 4 receptor deficiency.