The most significant disease related effects pertain to the proteins Tau/p-Tau (increase) and amyloid beta42 (decrease) as well as several analytes identified by metabolite profiling, particularly cysteine, several unknowns, cortisol and ornithine, including minor components arginine and citrulline, most of which are best correlated with light AD. The gene discussed is MAPT; the disease is Alzheimer disease.