In addition, our previous work showed that the PI3K/AKT/FOXO3A axis is a critical regulator of CD44+/CD133+ progenitor populations within prostate cancer cells, and that FOXO3a-dependent gene expression is inhibited in CD44+/CD133+ prostate cancer progenitors versus CD44+/CD133+ cell population. Here, PROM1 is linked to Familial prostate cancer.