In the present study, we aimed to determine whether telmisartan provides neuroprotection against DA cell death in a mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of parkinsonism, and whether PPAR-γ activation plays a major role in any such neuroprotection. Here, PPARG is linked to Parkinson disease.