The purpose of the present work was to study the effects of chronic allergy on markers for inflammation and AD neuropathology, including immunoglobulins, inflammatory cytokines, tau-phosphorylation and β-amyloid precursor protein (APP) in the brain in a model of chronic allergy in mice, to better elucidate the mechanisms behind a potential connection between two highly prevalent diseases, AD and allergy. This evidence concerns the gene APP and allergic disease.