In the present study, we have demonstrated that peripheral inflammation associated with a chronic model of airway-induced allergy modifies the immune status of the brain, as reflected by increased intracerebral levels of IgG and IgE, enhances tau-phoshorylation, but does not affect the APP levels, in the brain of two different mouse strains, Balb/c and C57B6. The gene discussed is IGHE; the disease is allergic disease.