Importantly, pre-incubation of B cells with the SHP-1-binding peptide of ITIM domain of LAIR1 abrogated the inhibiting effect mediated through LAIR1 engagement in HD and SLE patients, whereas the scrambled peptide, used as a control, did not affect the LAIR1-mediated inhibiting signal (fig. The gene discussed is LAIR1; the disease is Huntington disease.