We found that LAIR1 was expressed by most if not all CD20+CD27− naïve B cells in any kind of patients or HD; likewise, more than 70% of CD20+CD27+ memory B cells were LAIR1+ in SLE, MCTD, SSc and HD, suggesting no evident imbalance of naïve and memory B cell subsets in patients analyzed (fig. This evidence concerns the gene CD27 and mixed connective tissue disease.