A strong p65 nuclear translocation was induced upon sIgM engagement in HD similar to that observed in SLE patients (from basal level of 10–15% to 65–80%) In B cells of HD, LAIR1 oligomerization was able to inhibit the p65 subunit NF-kB activation induced via sIgM engagement from 65% to 35%. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.