We also found that there are different sets of risk variants associated with childhood and adulthood BMI; that the effects of FAIM2 and MAP2K5, both genes from a cell metabolism-related pathway, vary significantly with age; that FTO influences both childhood and adulthood BMI; that effects on obesity through appetite changes can be modified during prenatal development; and that multiple variants with weak or absent effects alone can jointly exert a large longitudinal effect. This evidence concerns the gene MAP2K5 and obesity due to melanocortin 4 receptor deficiency.