For example, HBx may promote tumor spreading by facilitating integrin-mediated cell migration and regulating the adhesion-deadhesion balance of the cells in the primary tumor site [4], enhancing CD44-mediated HA-interaction efficiency and modifying the migratory properties of transformed hepatocytes [5] and inducing matrix metalloproteinase (MMP) activation [6], [7], [8]. This evidence concerns the gene CD44 and neoplasm.