Unpaired t-test confirmed the findings from the MTMA; expression of the p85 subunit and the p110α subunit were significantly higher in adenocarcinomas than in squamous cell carcinomas (P<0.0002 for p85 and P = 0.0266 for p110α), as shown in Figure 2, panel C & D. Here, PIK3R1 is linked to adenocarcinoma.