When the mean RCV of each region was analyzed between the patient and control groups, patients with AMD had significantly higher RCV than controls at VEGFA and CFH (2.03 vs. 1.92 for VEGFA, p<0.01, 2.01 vs. 1.97 for CFH, p<0.01), and lower RCV at ARMS2/HTRA1 (1.97 vs. 2.01, p<0.01, Table 4). This evidence concerns the gene CFH and age-related macular degeneration.