When the mean RCV of each region was analyzed between the patient and control groups, patients with AMD had significantly higher RCV than controls at VEGFA and CFH (2.03 vs. 1.92 for VEGFA, p<0.01, 2.01 vs. 1.97 for CFH, p<0.01), and lower RCV at ARMS2/HTRA1 (1.97 vs. 2.01, p<0.01, Table 4). The gene discussed is VEGFA; the disease is age-related macular degeneration.