To confirm the tumor specificity of 2C5 mAb covalently attached to the nanoplatform, the Alexa Fluor 680-labeled nanobioconjugates (control P/IgG, P/2C5) or P/2C5/TfR were injected through the tail vein of mice and images were taken 24 hours after the drug injection. Here, TFRC is linked to neoplasm.