It is of interest that SYK is not present in the MLS and ChAc-related shared kinase network, suggesting either abnormal LYN activation, possibly SYK-independent as we recently reported in ChAc red cells [34], or changes in the accessibility of the membrane docking site for LYN in abnormal red cells from ChAc and MLS patients. The gene discussed is LYN; the disease is chorea-acanthocytosis.