In 1997, Munier et al. [7] reported 4 different missense mutations in TGFBI at the CpG dinucleotide of 2 arginine codons: an R555W mutation in a family with GCD1, an R555Q mutation in a family with Reis-Bücklers corneal dystrophy (RBCD), an R124C mutation in 2 families with LCD1, and an R124H mutation in 2 families with GCD2. This evidence concerns the gene TGFBI and Reis-Bücklers corneal dystrophy.