TP53 and malignant colon neoplasm: Song et al. [54] demonstrated that miR-215 overexpression in a colon cancer cell line reduced the proliferation rate and led to improved cell-cycle control, probably due to an increased expression of the cell-cycle control genes p53 and p21. Duan et al. [55] showed that miR-299-5p expression increased downstream of the tumor suppressor PRDM5 in HEK293 cells.