In this report we found no association of FGA rs6050 with plasmatic fibrinogen activity, but the fact that rs6050 is a missense SNP and that the amino acid substitution is considered as 'possibly damaging' by Polyphen 2 indeed suggest that the risk for DVT is conferred by an alteration of fibrinogen-alpha chain function. The gene discussed is FGA; the disease is deep vein thrombosis.