In particular, it has recently been shown that soluble hyperphosphorylated tau protein disrupts normal synaptic transmission in Drosophila (Cowan et al. 2010), mouse (Hoover et al. 2010), and giant squid (Moreno et al. 2011) neurons independently of neurodegeneration or loss of synapses, suggesting that this is an early event in the evolution of cognitive impairment associated with tauopathies. Here, MAPT is linked to tauopathy.