For example, in response to a lifestyle intervention to decrease caloric intake and increase energy expenditure (TULIP, n = 1576), carriers of the rs7903146 (TCF7L2) risk allele, who had impaired glucose tolerance prior to the intervention, showed an increase in post-glucose-load insulin secretion (adjusted for change in BMI), which was not shown in non-carriers (Heni et al. 2010). The gene discussed is INS; the disease is Impaired glucose tolerance.