The identification of differential phosphorylation in subunits of clathrin (CLTC and CLTCL1), spectrin (SPTBN1 and SPTBN2) and synapsin (SYN1) as well as the identification and validation of dynamin (DNM1) (Fig. 3) reinforces the impairment of synaptic transmission in MDD [16]. The gene discussed is CLTC; the disease is major depressive disorder.