On the other hand, miR-181b was apparently worse predictor of the stable disease compared to the other 2 prognostic markers, in that, among sequential specimens from this patient category, the properties were observed in 7 cases that have CLL cells with low expression of ZAP-70 and mutated IGHV, whereas only 3 cases did not showed the properties and had CLL cells with high expression of ZAP-70 and unmutated IGHV (Table 2). Here, ZAP70 is linked to B-cell chronic lymphocytic leukemia.