BRCA1 and ovarian cancer: There was some suggestion of a possible association between this SNP and ovarian cancer risk for BRCA1 mutation carriers with risk in the opposite direction (HR for ovarian cancer = 1.14, 95% CI: 1.00 to 1.30, P-trend = 0.06) especially among rare homozygotes (ovarian cancer HR for GG = 1.67, 95% CI: 1.05 to 2.64, P-homozygotes = 0.03).