In contrast, the OR estimates were similar for ER-positive and ER-negative breast cancer for SNPs rs2380205 (near ANKRD16 and FBXO18), rs704010 (upstream of ZMIZ1) and rs10771399 near PTHLH. In a separate GWAS that included mainly cases with two primary breast cancers or a family history of the disease, SNP rs865686 at 9q31.2 was found to be associated with risk for breast cancer, OR = 0.89 (95% CI: 0.85 to 0.92), but no estimates by ER status were reported [17]. The gene discussed is PTHLH; the disease is breast cancer.