The findings in patients with vasculitis are of particular interest since LN with a focal segmental glomerular pattern (WHO class III), which had the highest HMGB1 levels in our study, has been considered to have features and possibly immune mechanisms similar to those of lesions of systemic vasculitis [32] in comparison with the more widespread global pattern characterized by more pronounced immune depositions seen in patients with class IV. The gene discussed is HMGB1; the disease is necrotizing vasculitis.