As already used to analyze the formation of the Dnmt1/PCNA-including complexes and its recruitment on DNA in glioma cells, we used Proximity Ligation In Situ Assay (P-LISA) and ApoTome technology to dissect the dynamic of formation of the Dnmt1/PCNA-including complex and its recruitment on DNA during the different phases of cell cycle [4]. This evidence concerns the gene DNMT1 and glioma.