The selective inhibitor of mTOR, rapamycin, exhibiting only cytostatic effects when used as a single agent in MM models in vitro, mediated a significant potentiation of dexamethasone-induced apoptosis and suppressed constitutive, serum-, IGF-1-, and IL-6-induced survival in MM cell lines, in purified cells from MM patients (74). This evidence concerns the gene MTOR and Miyoshi myopathy.