The prime focus of our research interest has in recent years been the IGF-1, a cytokine not only providing survival and growth benefits to the malignant plasma cells by autocrine stimulation and by paracrine signaling from the surrounding tumor stroma (38), but also by its function as a chemoattractant of MM cells guiding the tumor cells to the preferable site of growth in the bone-marrow compartment (42). This evidence concerns the gene IGF1 and Miyoshi myopathy.