Furthermore, elevated levels of c-FLIP in tumor tissue from patients with colorectal cancer [80,81], bladder urothelial cancer [82], cervical cancer [83], Burkitt's lymphoma [84], non-Hodgkin's lymphoma [85], and head and neck squamous cell carcinoma (HNSCC) [86], and have been correlated with a poor clinical outcome and could be a reliable prognostic factor in these type of cancer. The gene discussed is CFLAR; the disease is head and neck squamous cell carcinoma.