Increased expression of c-FLIP has been shown in cell lines from various types of cancers including colorectal [69,70], pancreatic [71,72], ovarian [73,74], gastric [75], breast [76,77], prostate [78], melanoma [79], glioblastoma [80], and it is implicated in TRAIL resistance and chemotherapy resistance. The gene discussed is CFLAR; the disease is melanoma.