Interestingly, a deficiency in the adenomatous polyposis coli (APC) gene and subsequent activation of β- catenin can also lead to repression of c-FLIP expression through activation of c-Myc [125], c-FLIP upregulation may contribute to the carcinogenesis and aggressiveness of endometrial carcinomas and may serve as a useful prognostic factor for this tumor [24,126]. The gene discussed is CFLAR; the disease is endometrial carcinoma.