We have used lipocomplexes of c-FLIP siRNA to successfully knock down the c-FLIP gene and induce spontaneous apoptosis in MCF-7 breast cancer cells in vitro [142] (Table 2), and in vivo by directly injecting the c-FLIP siRNA lipocomplexes into MCF-7 mouse xenografts [142]. Here, CFLAR is linked to breast carcinoma.