Panner et al. [114] initially reported that a novel phosphatase and tensin homologue (PTEN)-Akt-atrophin-interacting protein 4 (AIP4) pathway regulates c-FLIPS ubiquitination and stability in glioblastoma multiforme (GBM) cell lines and xenografts. The gene discussed is PTEN; the disease is glioblastoma.