CFLAR and hepatocellular carcinoma: Interestingly, phosphorylation of c-FLIP variants by CaMK II appears to promote c-FLIPL recruitment to the DISC and inhibit TRAIL-induced apoptosi [118,119], but phosphorylation of c-FLIPL by protein kinase C or the bile acid glycochenodeoxycholate results in decreased c-FLIPL recruitment to the DISC and increased the sensitivity of hepatocellular carcinoma cells to TRAIL-triggered apoptosis [120].