Phosphoglycerate kinase (PGK) deficiency (OMIM 300653) is one of the relatively uncommon causes of hereditary non-spherocytic hemolytic anemia (HNSHA) which has gained the attention of physicians of different fields because a defective enzyme activity may also cause rhabdomyolysis, mental retardation, and various neurological disorders [1]. Here, PRKG1 is linked to congenital nonspherocytic hemolytic anemia.