VEGFA and neoplasm: Of the numerous growth factors and cytokines that have been shown angiogenic effects, vascular endothelial growth factor (VEGF), a glycoprotein that has mitogenic activity on vascular endothelial cells, is one of the most critical and specific angiogenic factors regulating normal physiological and pathological neovascularization such as tumor angiogenesis [6], [15]–[17].