ALG8 and early-onset autosomal dominant Alzheimer disease: They are ALG8 related to congenital disorder of glycosylation, DGKE related to diversity of adult human height, GNA12 related to major depressive disorder, KLF11 related to type-II diabetes, MMAB related to dyslipidemia and coronary artery disease, and LRPAP1 related to Alzheimer's Disease and many other diseases.