Expression of various AD-related human proteins e.g., amyloid-β (Aβ) and Tau, in the Drosophila model system results in animals displaying many of the histological hallmarks of AD seen in humans [4], as well as a correlation of lifespan to aggregation propensity of the protein or peptide expressed [5] which surpasses that of corresponding rodent models. Here, MAPT is linked to Alzheimer disease.