Meanwhile, SSD-specific pathways contain cytokine-cytokine receptor interaction, GPCRDB class A rhodopsin like, MAPK signaling pathway, neuroactive ligand receptor interaction, calcium signaling pathway, breast cancer estrogen signaling pathway, purine metabolism, insulin signaling pathway, cell adhesion molecules and Toll like receptor signaling pathway(Figure 1C). The gene discussed is INS; the disease is breast carcinoma.