A recent study showed that inhibition of ATM or CHK2 is sufficient to sensitize p53-deficient tumor cells, but not p53 wild-type cells, to genotoxic chemotherapeutic agent cisplatin or doxorubicin [32], suggesting that combination of cisplatin or doxorubin with ATM or CHK2 inhibitors could benefit patients carrying p53 mutant tumors. This evidence concerns the gene ATM and neoplasm.