CD4 and infection: Among the individual interventions, those with the largest effect on reducing cumulative new infections over 20 years were increasing the annual testing rate among HIV-infected MSM from 24% to 48% (associated with 15.3% fewer infections), increasing viral load suppression among persons receiving ART from 80% to 90% (associated with 10.8% fewer infections) and initiating ART at a CD4 count of 500 cells/mm3 (associated with 8.5% fewer infections) (Table 2).