Our data show that severity of HIV disease, low CD4+ count, insulin resistance, autoimmunity, metabolic syndrome, total obesity, hypertension, type 2 diabetes, gout, myocardial infarction, and ischemic stroke are emerging in Central Africans with HIV/AIDS because of demographic transition, lifestyle changes, low CD4+ count, ARV exposure, and later stages of HIV disease, but not from atherogenic dyslipidaemia [25, 25]. The gene discussed is CD4; the disease is obesity due to melanocortin 4 receptor deficiency.