In a randomized, controlled, double-blinded intervention study, insulin resistant and vitamin D deficient (serum 25OHD < 50 nmol/L) subjects supplemented with vitamin D (4000 UI, daily, for 6 months) had improved serum 25OHD level, insulin sensitivity and insulin resistance when compared to controls, while no effects were observed on lipid profile, C-reactive protein and insulin secretion [10]. This evidence concerns the gene INS and Insulin resistance.