For example, NPM-ALK, which is the most common fusion in ALK-positive ALCL (85%), exhibits a nuclear and cytoplasmic staining pattern because the heterodimer of NPM and NPM-ALK localizes in the nucleus and the homodimer of NPM-ALK in the cytoplasm; CLTC-ALK exhibits a cytoplasmic granular pattern because it localizes in the small vesicles. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.