An oxygen- and VHL/PHD-independent ubiquitination and proteasomal degradation of HIF-1α was observed after incubation of tumor cells with geldanamycin [32]–[34] and the small molecule inhibitor NVP-AUY922 has been shown to reduce HIF-1α levels in human tumor xenografts [35]. The gene discussed is VHL; the disease is neoplasm.