SMAD1 and neoplasm: Figure 6A shows the log10 transformed p-value of the t-test of such comparisons in each tumor type. The first six TFAs, i.e., HLF, ELK1, JUN, SMAD1, STAT6 and c-MYC, are significantly (p<0.05) altered in the PTEN negative group in all three cancers. STAT6 TFA is decreased while the others TFA are increased in the PTEN negative group. The degree of overlap of the tumor type-specific PTEN-controlled TFAs is summarized by a Venn diagram in Figure 6B.