To determine whether TFAs deducted from PTEN-inducible MEF reflect PTEN functional status in vivo, we examined the TFAs, based on the gene expression datasets we have in hand, of three well-established murine prostate cancer models, i.e. the Pten null [29], the mAKT1[24], and the hi-c-Myc[30] models (Figure 3A), and then categorized the TFs into subgroups according to alterations of their activities in these mouse models (Figure 3B). This evidence concerns the gene MYC and Familial prostate cancer.