The effect of the SNP in PREP1 was clearly independent of the year of AIDS diagnosis, since in both groups there were significantly fewer heterozygous individuals for SNP rs2839619 among cases than controls (p = 0.001 and p = 0.008 for the “AIDS diagnosis ≤1990” and the “AIDS diagnosis >1990 group”, respectively) (Table S3). This evidence concerns the gene PKNOX1 and AIDS.