Confirming our results on paraffin sections, E-cadherin expression was infrequent on melanoma cell lines, in line with the known E-cadherin downregulation by metastatic tumor cells [37] and corresponding to the diminished expression of KLRG-1 by CD8 T-cells found in TILN (Figure 4). The gene discussed is KLRG1; the disease is metastatic neoplasm.